After having carried out the first artistic activities under the guidance of his father Basilio, in 1907 he held, together with his brother Tommaso, his first personal exhibition in the rooms of the Milanese Artistic Family.
In 1909, again with his brother Tommaso, he set up an exhibition in the Galleria Druet in Paris, participating in the Salon d'Automne in the same year . In 1911 he organized an exhibition of pastel drawings in the reduced of the Teatro dell'Opera in Rome. Between 1914 and 1915 he collaborated in La Grande Illustration published by his father Basilio with drawings and graphic illustrations, exhibiting in 1917 at the Salone della Stampa and in the Central Art Gallery in Milan. Participate in the First World War.
In Rome, in 1919, he held a personal exhibition at the Galleria Bragaglia and on that occasion he met Carlo Carrà who then allowed the transfer of the exhibition to Milan in the Galleria Lidel. In 1920 he settled permanently in Milan where he enthusiastically attended the poet Clemente Rebora, from whom he confessed that he had drawn inspiration for the realization of some of his works.
From 1928 to 1932 he traveled between Italy and Paris where, in 1937, he was awarded the gold medal at the International Exposition. In 1938 he made the sets for the opera Margherita da Cortona, represented at the Teatro alla Scala.
From 1928 to 1942 he is present at all editions of the Venice Biennale of Art, and in the 1948 edition he will have a personal room.
From 1938 he resides in Portofino, which becomes a source of inspiration for his late works. Between 1937 and 1938 he created a large mosaic in the new station of Messina Marittima, depicting Mussolini who, on a visit to Palermo, "elevated Sicily to the burden of being the Center of the Empire".
In the 1950s he created for the Italian ceramic company of Laveno a series of drawings (about 40) named, Italy seen by Michele Cascella. These were used for the decoration of important tableware made by the Laveno manufactory.
After the Second World War his exhibitions abroad were more frequent: Paris (in the fifties and sixties) but also South America (especially Buenos Aires and Montevideo) and the United States. And in the USA, in California, he will settle for long periods of time, alternating periods of stay in Italy (he has resided for a few years in the countryside near Colle Val d'Elsa) and in Europe. The most represented subjects are flowers, wheat fields and poppies, the landscapes of Abruzzo and Portofino. The anthological exhibitions of this period were important.